"Intensive research ... has convinced me that the human organism can protect itself against infection virtually completely by proper nutrition." - Dr B P Sandler
Essential nutrient
Vitamin C is an essential nutrient for the human body. Science describes it chemically as 2-oxo-L-threo-hexono-1,4-lactone-2,3-enediol, or L-ascorbic acid, L-ascorbate or C6H8O6 - take your pick. It has a molecular mass of 176.14 grams and is so named for its active properties in fighting scurvy (a meaning ‘no' and scorbutus ‘scurvy').
Vitamin C is a form of sugar acid that appears white to yellow in a crystal or powder form and is water-soluble. It is found most famously in citrus fruits but also in leafy greens, a staple ingredient used to fortify foods, and is familiar to many as a childhood vitamin supplement, one of the most important for your continued wellbeing.
Humans cannot generate vitamin C
It is unfortunate then, that while it is synthesised internally by all but a few mammals, humans suffer from a genetic deficiency which prevents us from generating vitamin C in our bodies. Whereas most mammals can synthesise this vital nutrient with glucose produced from glycogen by enzymes in the liver,[1] our only hope of getting C is through our diet. An associate of Pauling's, Dr Matthias Rath, comments:
"Animals don't get heart attacks because they produce vitamin C in their bodies, which protects their blood vessel walls. In humans, unable to produce vitamin C (a condition known as hypoascorbemia), dietary vitamin deficiency weakens these walls. Cardiovascular disease is an early form of scurvy. Clinical studies document that optimum daily intakes of vitamins and other essential nutrients halt and reverse coronary heart disease naturally.
The single most important difference between the metabolism of human beings and most other living species is the dramatic difference in the body pool of vitamin C. The body reservoir of vitamin C in people is on average 10 to 100 times lower than the vitamin C levels in animals."[2]
Humans absorb C Lucky for us, the human body is an astounding system with a remarkable capacity for self-regulation and correction. DNA itself is a three-out-of-four, error-correcting digital code with stop and start bits to parse the assembly instructions of every protein of an organism.
Unlike the 4,000 or so species of mammal which produce vitamin C internally, the human genetic code compensates for our defect by having red blood cells specifically designed for increased absorption of C. Haemoglobin is able to absorb the oxidised version of the nutrient, deoxidise it in the cell, then transport the active ‘antioxidant' to where it is most needed.[3]
Red blood cells ensure our bodies are kept adequately supplied, and are even able to recycle the nutrient to some degree. There's just one hitch. We've got to eat or drink vitamin C to get it into the system in the first place. What a disappointment, then, that our peers don't do more to ensure everyone is fully briefed.
Cooking kills it
When was the last time someone told you on TV that cooking destroys vitamin C? Never.
How many times on TV has a ‘celebrity' chef shown you more inventive ways to murder your food with heat? Five times a night, and they swear at you for getting it wrong.
So what percentage of see-no-evil, hear-no-evil humanity goes through an entire British, American and Australian winter cooking everything and ending up sicker than Gordon Ramsey's dog? The vast majority.
How many are destined to end up dying of a disease not even their livestock are dying from? The vast majority.
How many will be talked into taking ‘life-saving' drugs and other redundant nostrums before they finally expire? The vast majority.
Room for a little improvement, wouldn't you say?
Not just an acid
Dr Tim O'Shea writes:
"Most sources equate vitamin C with ascorbic acid, as though they were the same thing. They're not. Ascorbic acid is an isolate, a fraction, a distillate of naturally occurring vitamin C. In addition to ascorbic acid, vitamin C must include rutin, bioflavonoids, Factor K, Factor J, Factor P, Tyrosinase, Ascorbinogen, In addition, mineral co-factors must be available in proper amounts. If any of these parts are missing, there is no vitamin C, no vitamin activity. When some of them are present, the body will draw on its own stores to make up the differences, so that the whole vitamin may be present. Only then will vitamin activity take place, provided that all other conditions and co-factors are present. Ascorbic acid is described merely as the "antioxidant wrapper" portion of vitamin C; ascorbic acid protects the functional parts of the vitamin from rapid oxidation or breakdown."[4]
It's a complex
So vitamin C is a complex. The ascorbic acid and ascorbate (an ion of ascorbic acid) are required for a variety of essential metabolic functions. They help metabolise fats and proteins and aid recovery from wounds. In addition to vitamin E and two amino acids, lysine and proline, vitamin C is vital for the creation of collagen, the chief protein in soft and connective tissue throughout the body.
Vitamin C, therefore, helps provide us with skin, hair, corneas, tendons, muscles, ligaments, bones, organs, cartilage, and the basis for the very structure of our cells. Without it we simply fall apart, which is scurvy.
Last but not least, vitamin C strengthens the piping of our cardiovascular system, and its deficiency is one of the chief factors in the leading cause of disease death today, heart disease, which destroys one in every two and half of us (if you can picture such a creature).
And in 50% of those deaths, Andrew Saul reminds us, the first symptom is death.[5] An adequate level of vitamin C in the diet, therefore, is vital over the long-term. Failure to do this gets you dead. Badly.
What is it good for?
Like a good Toyota, you get your mileage with vitamin C. It's a powerful antihistamine, antiviral, antitoxin, and Halle Berry uses the powdered stuff mixed with water to exfoliate her First Division visage. And, as if all that's not good enough, vitamin C acts as a particularly effective antioxidant, neutralising cell-damaging free radicals or oxidative elements in the body.
As we age, we slowly oxidise (biologically ‘rust'). An antioxidant is a type of molecule able to slow down or prevent this oxidation process. Oxidation itself is a chemical reaction crucial to life, but one that can be damaging too.
The body employs various reducing agents and enzymes in order to control this vital but potentially harmful system. If not properly controlled, oxidation releases adverse levels of peroxides and free radicals which damage the cell and its DNA. Antioxidants like vitamin C stop these reactions by removing the free radicals and becoming oxidised themselves.
If there are more free radicals than the antioxidants and enzymes can control, the body suffers oxidative stress, which can induce diabetes, cardiovascular disease, hypertension, and chronic inflammatory diseases. Vitamin C is a major player in preventing this from occurring.
Linus Pauling PhD, often known as the ‘Father of Vitamin C' and twice awarded the Nobel Prize, declared that large intakes of up to 10 g of vitamin C each day aids anti-cancer activity within the body. It also assists in repairing damaged arteries and removing arterial plaque for heart disease sufferers. Pauling was largely derided for making these statements, and we'll examine the controversies in a minute, yet he lived into his nineties.
Today, much higher doses of C complex are used by many practitioners for cancer/heart/stroke patients in nutritional therapy who believe Pauling was right, and that the popular nutrient is indispensable to the body in its fight to regain health.
Dietary sources of vitamin C - fruit and veg
Vitamin C is found in abundance in fruits and vegetables, and also in some meats. Rose hips, blackcurrant, peppers, kiwi, guava, broccoli, and nature's most maligned Christmas treat, the Brussels sprout, are all high in vitamin C.
Not only are these foods packed with nutrients in their organic form (unlike meat), they are low in fat and do not need to be cooked to be eaten. If you wish to destroy all the nutrients, enzymes and vitamin C that make fruit and vegetables healthy in the first place, simply fire up the pan and cook ‘em.
Bioflavonoids
Dr Albert Szent-Gyorgi, 1937 Nobel laureate for his isolation of vitamin C, later found other factors intrinsic to the action of C. Originally believed to be a single nutrient, Vitamin C became the subject of further testing by Szent-Gyorgi, who fought long and hard to have the co-factor (bio)flavonoids included.
Bioflavonoids are derived from plant pigments known as flavonols and flavones and are found in many of the same fruits and vegetables rich in vitamin C. Szent-Gyorgi argued that they were essential to human health and coined the new bioflavonoids ‘Vitamin P'. Though they are widely accepted today for their health benefits and are available in hydroxylated and methoxylated forms, the term ‘Vitamin P' was less well received by our medical czars.
Bioflavonoids have great antioxidant properties but in a different way to C. While the body welcomes ascorbic acid and the ascorbates, it recognises bioflavonoids as a foreign compound and acts quickly to flush them from the system. This increases levels of uric acid and serves to expel excess free radicals and other toxins from the body, aiding in the antioxidant process.
While different kinds of bioflavonoid help the body in different ways, all are extremely useful. Those found in citrus fruits increase the absorption of vitamin C in our cells, aid blood vessel permeability and blood flow, and exhibit anti-allergy, anti-inflammatory, anti-microbial and anti-cancer properties.
In a nutshell? Bioflavonoids are seriously good for you.
Meat
Certain meats also contain vitamin C. This is because some animals have high internal levels of C which build up in certain tissues. Liver is the best source of meat for C, but loses up to 100% of its C content when cooked. Unfortunately, the muscles that make up the bulk of western carnivorous diets also happen to be the cuts of meat with the lowest concentrations of vitamin C. We don't like to eat meat raw. Carnivores do.
In 1928, the Arctic anthropologist Vilhjalmur Stefansson emulated the Inuit diet to test a theory. Despite having almost no plant material in their diet, the native people avoided scurvy while European explorers suffered heavily. Both ate meat-based diets. Living exclusively on only lightly cooked meat for a year without any ill-effects, Stefansson was able to prove that cooking the meat destroyed specific nutrients within, later discovered to be vitamin C.
Milk
Human milk also contains useful amounts of C for breast-feeding babies. Mums who have good levels in their own bodies produce milk twice as fortified with the nutrient than found in raw cow's or goat's milk. Once pasteurised, milk loses most of its C content.
Although baby formulas boast that they are fortified with vitamins and just as good as breast milk, the heating and storage that goes with such products wrecks the vitamin C content. Formula well fortified with vitamin C might well contain very little after transit, storage and heating. Nature knows best.
Supplements
Diets being what they are these days, not everyone chooses to get their vitamin C through eating raw fruit and veg, nor chomping lightly cooked slivers of liver. Many choose the world's most popular vitamin supplement instead - you guessed it, vitamin C. Available in caplets, powders, capsules, multivitamin and antioxidant formulations, C supplements are many and varied. If you choose to take a vitamin C supplement, ensure your intake is spread throughout the day to maximise absorption and that the supplement contains bioflavonoids to aid vitamin C metabolism. Steven Hickey PhD writes:
"An individual who wanted protection from, say, the common cold by taking vitamin C, would raise their blood levels more effectively by taking divided doses or slow-release formulations.... If a single dose of vitamin C raises blood levels for about six hours or one quarter of the day, the subject is unprotected for the other three quarters of the time.... The biochemical data supports Pauling's hypothesis that, for a large proportion of the population, the optimal dose of vitamin C is several grams a day.... A single megadose tablet will only raise blood levels for a short period and is likely to be therapeutically ineffective. The aim is to raise plasma levels consistently and this requires either multiple tablets taken at short intervals throughout the day, or the use of slow-release formulations." [6]
Conclusion
Although the levels of vitamin C in food depend on the type of plant, the soil it grew in, freshness, how it was stored or prepared, etc., the following guidelines will ensure a good dietary intake of vitamin C can be achieved.
Raw food rocks! Cooking and heating destroys many of the active components of vitamin C. If you boil a saucepan of vegetables for too long you risk having more vitamin C in the pan water than the food. Copper cooking vessels also reduce the C content of your food.
Fresh is best! As food is stored, the vitamin C content gradually decomposes. An orange in your lounge fruit bowl will lose 50% of its vitamin C content in two weeks. The fresher the food, the more vitamin C it will retain. Correct storage in a cool place, such as a refrigerator, also helps maintain vitamin C content.
Fruit and veg! A diet comprising 80% plant-based, organic fruits and vegetables with 60%-plus consumed raw is the way to go. Vegetable juices are highly recommended - more so than fruit juices, which contain concentrated sugar and acid. Patients recovering from serious illness would do well to keep their raw food ratio high, and vegetable juices enable them to achieve this quickly and effortlessly.
Resources
The Essential Guide to Vitamin C by Phillip Day and Nick Cockayne
Vitamin C Complex plus Bioflavonoids (400 g tub)
Footnotes [1] Bánhegyi G, Mándl J "The hepatic glycogenoreticular system", Pathol Oncol Res 7 (2): 2001, pp.107-110
[2] Rath, M Why Animals Don't Get Heart Attacks - But People Do! MR Publishing, 2000, p.10
[3] How Humans Make Up For An 'Inborn' Vitamin C Deficiency.
www.sciencedaily.com/releases/2008/03/080320120726.htm
[4] www.thedoctorwithin.com
[5] www.orthomolecular.org
[6] Hickey S and H Roberts Ascorbate, Lulu, 2004
[7] The New England Journal of Medicine, 7th February 1991
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