"All children under five are at risk of developing rickets because of their couch potato lifestyles, the government's Chief Medical Officer said today.
Professor Dame Sally Davies says children aged six months to five should be given vitamin D supplements - particularly during the winter.
Her advice comes after figures revealed a dramatic increase in the crippling disease in children who aren't exposed to sunlight for long enough, because they stay indoors playing computer games or watching TV.
Dame Sally, the Director General of Research and Development and Chief Scientific Adviser for the Department of Health and NHS, said children should take seven micrograms of the sunshine vitamin every day."
*** Phillip Day's Comment
Good advice, coupled by a risible recommendation. 7 IU/day? According to the latest science
, D3 supplementation should always be varied according to bodyweight. Therapeutic supplementation is far higher. Research shows the unequivocal benefits of vitamin D both in the prevention and treatment of cancer as well as rickets and other diseases. Lack of, and fear of sunshine, combined with processed, cooked diets has become the, to-date, undeclared catastrophe of modern times. The Vitamin D Council writes:
"Technically not a ‘vitamin', vitamin D is in a class by itself. Its metabolic product, calcitriol, is actually a secosteroid hormone that targets over 1000 genes in the human body.
Current research has implicated vitamin D deficiency as a major factor in the pathology of at least 17 varieties of cancer as well as heart disease, stroke, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle wasting, birth defects, periodontal disease, and more. Vitamin D's influence on key biological functions vital to one's health and well-being mandates that vitamin D no longer be ignored by the healthcare industry nor by individuals striving to achieve and maintain a greater state of health." www.orthomolecular.org writes: "
If you search the US National Institutes of Health's Medline online database for ‘cancer vitamin D', you will find over five thousand papers... some dating back nearly 60 years.
It's true: physician reports on vitamin D stopping cancer have been ignored for decades. In 1951, T. Desmonts reported that vitamin D treatment was effective against Hodgkin's disease (a cancer of the lymphatic system).
That same year, 57 years ago, massive doses of vitamin D were also observed to improve epithelioma.
In 1955, skin cancer was again reported as cured with vitamin D treatment.
In 1963, there was a promising investigation done on vitamin D and breast cancer.
Then, in 1964, vitamin D was found to be effective against lymph nodal reticulosarcoma, a non-Hodgkin's lymphatic cancer.
The American Cancer Society has been obsessed with finding a drug cure for cancer. Pharmaceutical researchers are not looking for a vitamin cure. And when one is presented, as independent investigators and physicians have continuously been doing since 1951, it is ignored." Vitamin D RDA and sun-dosing
The recommended daily allowance for vitamin D in adults is set at 200-400 international units a day (IU). This is thought to be the level above which overt cases of the classic vitamin D deficiency disease rickets will not be observed. Alas, it's not that simple. You actually need around 4,000 IU/day just to maintain the vitamin D level you already have as an adult. Do you think government scientists know this already? Of course they do. To understand vitamin D's playing field a little better, consider the following.
Let's say you went out to the local park in June between 11am and 2pm, stripped completely naked and laid out on the grass. In the half an hour it took for the local police to arrest you, scientists say you can generate around 20,000 IU of vitamin D. Of course, the mitigating factors are skin pigmentation, where you are on the planet, cloud cover, pollution, speed of police, etc. Then you get bailed out at the station, return home with your clothes on, strip off again for a shower... and wash all that vitamin D down the plughole!
That's right. It takes around 48 hours for vitamin D to penetrate the skin. Being oil-soluble, vitamin D is broken down by soap and washed away in your power shower. To avoid this happening after adequate sun exposure (enough for you fair-skinned types to turn pinkish), wash off the skin with water and tend to the underarms and groin area separately. Smelly old farmers live longer - pungent but true. Dark-skinned folk need much more sun than light-skinned folk.
Watch to see when your shadow is shorter than you are. Dr John Cannell says this is a useful thumbnail to determine when you can make vitamin D. Unfortunately in the UK, your shadow is longer than you are for a good six months of the year. Trying to get sun exposure behind glass won't work either since the vitamin-D-making UVB wavelength is disrupted. UVA gets through, however, and that's not good news.
Every member of the population should take reasonable
sun exposure not only more seriously, but view it as one of the cardinal prerequisites for a longer life. If you have dark skin and have moved to a northern country, you are especially at risk from vitamin-D-deficiency problems. Numerous studies indicate that ‘all-cause mortality' is significantly higher if you are vitamin-D-deficient. Vitamin D testing
If you have cancer or other serious condition, the first thing to do is find out your blood serum level of D. You can do this even if you are healthy and just want to know. The test you should request from your GP is known as a 25(OH)D or 25-hydroxy D test for calcidiol, and is done using a blood sample. Do not get fobbed off with "Oh, you're a bit low, Marjorie." You need the figure and the calibration, i.e. 25 ng/ml or 75 nmol/L. If you end up with other calibrations, convert as follows:
10 ng/ml = 10μg/L (no change)
10 ng/ml = 24.96 nmol/L (1:2.5) The ng/ml and μg/L scales run as follows (UK, USA, etc.):
<20 ng/ml - grossly deficient
20-40 ng/ml - deficient
50-60 ng/ml - normal
70-90 ng/ml - therapeutic
>100-110 ng/ml - toxic threshold The nmol/l scale runs as follows (Australia, etc.):
< 50 nmol/L - grossly deficient
50 - 100 nmol/L - deficient
130 - 150 nmol/L - normal
170 - 190 nmol/L - therapeutic
>230 nmol/L - toxic threshold
Dr Bruce Hollis remarks that no circulating D3 can be found until levels are 40-50 ng/ml (100-125 nmol/l). By this measure, at least 85% of the US population are vitamin-D-deficient. Consider that America is below the 52nd parallel, so the UK and northern Europe will be far worse.
If your test comes back deficient, your vitamin D level should be raised using sunlight and/or supplementation, and then re-tested four weeks later to see if progress is being made. I encourage people to take 10,000 IU/day of D3 while they are getting tested and then adjust the supplementation accordingly (usually upward) and re-test in four to six weeks.
There are specially designed, electronic-ballast ‘safe' tanning beds, too, which emit predominant UVB wavelength. Dr Joseph Mercola recommends these but they are expensive and not to everyone's tastes.
The best choice is sunlight and/or vitamin D3 (cholecalciferol) supplementation. If you are pushing the limits with very high supplementation, the experts advise that you to get tested often and watch for calcium levels rising - an indication of the toxic threshold. There is a good margin for safety, however. Risks from toxicity with D3 are commonly overblown and true problems only come from overdosing for months on end.
For most people, D3 oral supplementation will be the only option during winter months. The level of supplementation is irrelevant, it's the serum level that matters. Dr Mercola states that normal healthy individuals can supplement 3,000 IU/day per 100lbs bodyweight and for those undergoing treatment for cancer or other serious illnesses, 5,000 IU/day per 100lbs bodyweight. Once again, if you are pushing the limits with oral supplementation to get your serum level up in a hurry, it is vital to monitor levels not only to avoid the aforementioned overdosing, but to ensure the therapeutic margin is gained.
Some people require huge initial doses of D3 to get them into the game (50,000-100,000 IU). However, I find that for most adults who have never supplemented, 10,000 IU/day for a month followed by 5,000 IU/day thereafter gets them optimised without delay. If in doubt, you simply won't know where you stand without testing and monitoring your level. Remember also that you weren't designed to take vitamin D orally, so you won't get all of the benefits associated with normal sun exposure, which is by far the most safe and efficient method of vitamin D production when done reasonably
"There is no way to know if the recommendations given below are correct. The ONLY way to know is to test your blood. You might need 4-5 times the amount recommended below. Ideally your blood level of 25(OH)D should be 60ng/ml."  AGE / ORAL DOSAGE
Below 5 years / 35 IUper lb per day
5-10 years / 2,500 IU/day
18-30 years / 5,000 IU/day
Pregnant women 5,000 IU/day TIP: If you miss a day's supplementation, simply tack it onto the following day. TIP 2: If you have a two year-old like I do whose allocation is 1,000 IU/day, and you have 5,000 IU capsules, give them one every five days. TIP 3: Now book a holiday!
Resources The Essential Guide to Vitamin D by Phillip Day Vitamin D3 (cholecalciferol) 5,000 IU x 240 softgels
Listen to the big gun against fluoridation
The governments of Australia, Canada, New Zealand, USA, Ireland, Britain and many other countries routinely fluoridate their citizens' water supplies.
Here, Dr. Paul Connett, Professor of Chemistry at St. Lawrence University in New York, gives a damning interview on the history of water fluoridation, the collusion of major industries to put certified toxic waste into your drinking water, and why government health authorities refuse to conduct scientific studies into the dangers of fluoridation.
Dr. Paul Connett, Professor of Chemistry at St. Lawrence University in New York, gives a damning interview on the history of water fluoridation, the collusion of major industries to put certified toxic waste into your drinking water, and why government health authorities refuse to conduct scientific studies into the dangers of fluoridation. After watching this video, you will never look at tap water the same way again. Connett describes how he initially thought people who opposed fluoridation were "a bunch of whackos," before conducting his own research which found that sodium fluoride was a toxic substance that contributed to a wide array of health defects. Heavy industry is barred from dumping this toxic waste into the sea by international law, but being able to sell it enables them to remove its hazardous characteristic and it becomes a product, explains Connett, polluting not only our water supply but also toothpaste and thousands of different foods.
Connett provides a detail run down of the many health problems caused by fluoride consumption, including dental fluorosis, which the Centers For Disease Control just recently announced was a problem for 41 per cent of children aged 12-15 in the United States, clearly indicating that children are being over-exposed to fluoride and that this is affecting other tissues and organs in the body, including bone disorders, a problem also wreaking havoc amongst adults in the United States as one in three now suffer from arthritis, which again is being caused by a build-up of toxic fluoride in the body. Connett also points to fluoride's connection with thyroid disorders.
There have now been over 100 studies involving animals which show that fluoride damages the brain, stresses Connett, which is a particular concern for newborn babies who are susceptible to fluoride build up because of their weak blood-brain barrier. Connett cites numerous studies which prove a link between moderate exposure to fluoride and lowered IQ.
Phillip Day's The Victory Tour 2011 The secret to life is...
Most of us have too much going on in our lives to plough through the massive amounts of often highly technical information, both good and bad, that gushes out of our medical institutions daily. Most, who actually read a newspaper or watch TV regularly, find themselves relying on news programs to give them any good news that may be springing out of all that medical research into which billions are invested annually. Sadly it's rare today to find any newspaper which prints useable information for personal use. Medicine must remain corporate to protect profits, after all. And that's where my forthcoming Victory Tour
comes in. The nitty gritty
I'll be covering the very latest answers and information science has produced - a compendium of the leading trouble-spots in health - what they are, what the symptoms are, what causes them, and what we can do about them. Often the solutions are that simple, a change of diet and lifestyle alone is required. Did you know that 80% of Australians over 35 are vitamin D deficient and therefore vulnerable to a whole host of conditions? How important is that?
Did you know that the top six causes of disease death in Australia stem from chronic malnutrition?Not much cop
Unfortunately, doctors are not being trained in nutrition, so most have little knowledge of the effects our environment and lifestyle can compel upon us. This is why the performance of modern medicine with disease is so appalling. Sometimes a death can be averted so simply. The amazing example of New Zealand farmer Allan Smith is a case in point. Allan fell seriously ill to the point where he was put on ECMO life-support after contracting white-out pneumonia through swine flu. His family was summoned to face what doctors believed was his inevitable demise. They were prevented from switching off Allan's breathing machinery, however, only after his sons threatened court action
if their father was not administered intravenous vitamin C and fast.
This was grudgingly done. However, Allan's recovery would have been swifter but for officialdom scoffing at ‘useless' vitamin C and repeatedly halting the treatment. Happily Allan recovered after the lawyers were called in. Watch his inspiring story on the Credence homepage to understand precisely what the average citizen is up against. These farmer's boys saved their Dad with information researched back in the 1940's! How much more will you accomplish after I've finished with you?Spreading the news at street level
Each of us comes into contact with dozens of people a week who grumble about their aches and pains or betray fear over a more serious illness. Or perhaps they know a friend or relative who is in trouble. This is a perfect opportunity for us to allay fears by sharing basic concepts of good health, and I've dealt with these in past tours
You don't need to get into the two-hour speech with everyone you meet. I was at the grocer's the other day and overheard the word cancer. It took two minutes. Acquaintances hold a lot of store in personal recommendation and sometimes investigate. With a well-aimed www.credence.org
wedged in their ear, a percentage may well ignore you and bolt for the doctor, but an ever-increasing minority will ponder. That's why they brought up the subject in the first place, remember?Change a life
Let's show compassion for someone's situation and help them where we can. Credence produces easy-to-read/listen/watch materials which deliver properly researched, vital information to inspire people to make changes, but we need your help. Do you have any idea how many people don't feel well and want someone to know about it? That someone is you! The New England Journal of Medicine
told us in 1991 that:
"90% of patients who visit doctors have conditions that will either improve on their own or are out of reach of modern medicine's ability to solve." 
But not out of reach of nutritional/orthomolecular medicine in many cases. Actually all most people need is a proverbial slap around the chops or prod in the right direction and they're on their way. Go through the EClub mailbag on my monthly bulletins and you'll see what I mean! There are miracles happening every day but sadly only for those who hear about it.
We have so many answers these days but can't get them out fast enough. People like Mike Adams, Andrew Saul, Joseph Mercola, the Food Matters crew and myself have to rely on troops on the street - that's you - to give wings to this thing. Opportunities crop up at barbecues, dinner parties, on a train or running a friend to work to save or improve a life. You don't have to get technical, just point them to a book or a website. Or bring them along to one of my Victory
meetings and I'll slap ‘em for you J
Thanks to the broadcasting embargo of proper, lifesaving information by our bought-and-paid-for media, there are opportunities a-plenty for those who want to help others. Every time someone calls up to say, "A friend introduced me to your website/gave me a book/lent me Food Matters
and it changed my life!", how many more were helped who never called? We get all the letters and emails so something's working.
As I write this, the flood waters are rising on Brisbane and other communities. All our thoughts and prayers at Credence are with those caught up in these calamitous events. Steve and I are on our way down in the next few weeks and will navigate in a dinghy if necessary to get to you (especially Rockhampton). May the Victory Tour
mark the launch of a new chapter in our lives of better health, happiness and peace of mind. What better mission can we have to occupy our time in 2011 than one which will not only play an important role in protecting and extending the lives of those we love, but spread the good news far and wide across Australia for the benefit of those who have yet to hear it.
See you soon!
Phillip and Credence Team Australia Further Resources Tour tickets, itinerary and more information
Measles, mumps, rubella, Hep B, cervical cancer, smallpox, AIDS, diphtheria, flu, pertussis, tetanus, etc., etc. Do you vaccinate, don't you vaccinate?
Dr Gary Null's excellent new film, Vaccine Nation,
tears the lid off the scaremongering and dangerous fraud behind the vaccine industry. Take some time TO WATCH THIS
and pass the link around to others.
It's at your fingertips
(OMNS Dec 3, 2010) Many readers wanting to learn more about nutritional therapeutics have sent in email requests for additional information. While the Orthomolecular Medicine News Service cannot answer these individually, we offer in this issue a directory of links to online resources that may prove valuable. Vitamin C and Cancer: What can we conclude?
Comments by Andrew W. Saul, Michael J. Gonzalez, Jorge R. Miranda-Massari, Jorge Duconge, and Fernando Cabanillas http://prhsj.rcm.upr.edu/index.php/prhsj/article/viewFile/546/384
Details of the Intravenous Vitamin C Treatment Protocol of Hugh D. Riordan, M.D. http://www.doctoryourself.com/RiordanIVC.pdf
and or http://www.riordanclinic.org/research/vitaminc/protocol.shtml
Access to Specifics of Nutritional Treatment Protocols http://orthomolecular.org/resources/omns/v06n25.shtml Journal of Orthomolecular Medicine
Online Archive http://orthomolecular.org/library/jom/index.shtml
41 years of JOM are now available as full-text pdf downloads, free of charge.
Orthomolecular Medicine News Service Online Archive http://orthomolecular.org/resources/omns/index.shtml
Online access to nearly 100 issues.
Directories for Finding a Nutritionally-Minded Doctor http://orthomolecular.org/resources/omns/v06n09.shtml
Archive of Natural Health Articles, in German
[Archiv der deutschsprachigen Artikel, auf DoctorYourself.com] http://www.doctoryourself.com/DeutschIndizieren.html
This project is being updated and expanded almost daily. Volunteer translators are welcome.
Orthomolecular Medicine for India http://en.wikipedia.org/wiki/Orthomolecular_Medicine_for_India
A new Wikipedia page devoted to the benefits of nutritional medicine for emerging nations.
Dr. Frederick R. Klenner's Clinical Guide to the Use of Vitamin C
is posted in its entirety at http://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
The complete text of Irwin Stone's book The Healing Factor
is posted for free reading at http://vitamincfoundation.org/stone/
A very large number of free-access, full-text papers on curing illness with vitamin C are posted http://www.seanet.com/~alexs/ascorbate
For more information on Vitamin C: http://www.vitamincfoundation.org/ http://www.cforyourself.com
Read Linus Pauling's complete 1968 paper on vitamin therapy at http://www.orthomed.org/home/pauling2.html
A 1974 Pauling paper on the same subject is posted at http://www.orthomed.org/home/pauling.html
Linus Pauling and colleagues show how vitamin C and the amino acid lysine may prevent and cure atherosclerosis. http://www.internetwks.com/pauling/
Heart Health http://www.health-heart.org/aFullSitePDF.pdf
is a free pdf download of a full-color book on preventing and reversing heart disease nutritionally.
Dr. Abram Hoffer explains why there is so much opposition to vitamin therapy at http://www.internetwks.com/pauling/hoffer.html
"Numerous studies show that certain synthetic food additives can have serious learning, behavior, and/or health effects for sensitive people." Learn what to do at http://www.feingold.org/research.php
Free email newsletter available at http://www.feingold.org/ON.html
There are doctors supportive of vegetarianism, and here they are: The Physicians' Committee for Responsible Medicine http://www.pcrm.org
. Free download of their "New Four Food Groups at http://www.pcrm.org/health/veginfo/vsk/4foodgroups.pdf Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource. Editorial Review Board:
Ian Brighthope, M.D. (Australia)
Ralph K. Campbell, M.D. (USA)
Carolyn Dean, M.D., N.D. (Canada)
Damien Downing, M.D. (United Kingdom)
Michael Ellis, M.D. (Australia)
Michael Gonzalez, D.Sc., Ph.D. (Puerto Rico)
Steve Hickey, Ph.D. (United Kingdom)
James A. Jackson, Ph.D. (USA)
Bo H. Jonsson, M.D., Ph.D. (Sweden)
Thomas Levy, M.D., J.D. (USA)
Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
Erik Paterson, M.D. (Canada)
Gert E. Shuitemaker, Ph.D. (Netherlands)
Jagan Nathan Vamanan, M.D. (India)
by Phillip Day
The power of Vitamin C revealed
(Ascorbic acid/ascorbates plus bioflavonoids, etc.)
Dr Linus Pauling, often known as the ‘Father of Vitamin C' and twice awarded the Nobel Prize, declared that large intakes of up to 10 g of the vitamin complex each day aids anti-cancer activity within the body and also assists in repairing damaged arteries and removing arterial plaque (atherosclerosis) for heart disease sufferers. Pauling was largely derided for making these statements yet lived to be 94.
Today, much higher doses of vitamin C complex are used by many practitioners for cancer/heart/stroke patients in nutritional therapy who believe Pauling was right and that the popular nutrient is indispensable to the body in its fight to regain health from cancer.
Heat destroys vitamin C.
This means that for every meal you cook, 100% of the vitamin C content has been destroyed. Many go through an entire winter cooking their food because they like something warm. Humans cannot make vitamin C in their bodies, unlike most mammals, so our only source of this valuable complex is dietary, hence the need for a high percentage of our diet to comprise raw, living, organic, whole plant foods.
Vitamin C - a disease preventing complex
Vitamin C is not one nutrient but a complex of factors common in fruits, vegetables and many other foods. Several studies have suggested that vitamin C may reduce levels of lead in the blood. Epidemiological studies have shown that people with elevated blood serum levels of vitamin C had lower levels of blood toxicity.
An examination of the data from the Third National Health and Nutrition Examination Survey, enrolling 4,213 youths aged 6 to 16 years and 15,365 adults 17 years and older from 1988 to 1994, found a correlation between low serum ascorbic acid levels and elevated blood lead levels. The authors conclude that high ascorbic acid intake may reduce blood lead levels.
Ascorbic acid or the non-acidic ascorbates (calcium or magnesium ascorbates) should be taken along with bioflavonoids and a healthy, majority-raw, alkalising, plant-based diet for optimum effects. Effective supplementing is all about obtaining optimal blood plasma levels of the nutrient, say Drs. Steven Hickey and Hilary Roberts in their book, Ascorbate:
"An individual who wanted protection from, say, the common cold by taking vitamin C, would raise their blood levels more effectively by taking divided doses or slow release formulations.... If a single dose of vitamin C raises blood levels for about six hours or one quarter of the day, the subject is unprotected for the other three quarters of the time....
The biochemical data supports Pauling's hypothesis that, for a large proportion of the population, the optimal dose of vitamin C is several grams a day.... A single megadose tablet will only raise blood levels for a short period and is likely to be therapeutically ineffective. The aim is to raise plasma levels consistently and this requires either multiple tablets taken at short intervals throughout the day, or the use of slow release formulations."
Mega-dose Vitamin C therapy
One of the greats of mega-dose vitamin C therapy was Frederick Robert Klenner MD, who was curing viral illness in the 1940's using large amounts of the nutrient. He advocated a therapeutic use of vitamin C amounting to 350 mg of vitamin C per kilogram body weight per day (350 mg/kg/day), in divided doses. A kilogram is about 2.2 pounds, so:
Which makes a mockery of the ridiculous 60 mg RDA set by government departments around the world. Andrew Saul PhD, editor-in-chief of The Journal of Orthomolecular Medicine, is a big fan of mega-dose vitamin C and has two of the best websites on the subject. He introduces us to Dr Robert Cathcart III, an orthopaedic surgeon and inventor of a widely used hip replacement prosthetic, who advocated doses of vitamin C, often in excess of 100,000 mg per day, to reduce severe inflammation.
In decades of practice, Dr Cathcart effectively administered such treatment to tens of thousands of patients, titrating the amount of C given to ‘bowel tolerance', i.e. to the point where dosage brought on diarrhoea, indicating a saturation of tissues. Many of his patients suffered from arthritis, back pain, or injury; some had ankylosing spondylitis. Andrew Saul writes:
"For those unable to obtain intravenous vitamin C, it is essential to pay special attention to one of the most important aspects of vitamin C therapy: dividing the dosage improves absorption and retention of vitamin C. High oral doses of vitamin C yield higher blood levels of the vitamin, and dividing the oral doses maintains those higher levels.Although initially seeming almost too obvious to mention, these are not self-evident concepts. Many a medical website and government-based dietary recommendation hinge on ignoring them.
Hilary Roberts, PhD, writes: "Stressed and even mildly ill people can tolerate 1,000 times more vitamin C, implying a change in biochemistry that was ignored in creating the RDA. In setting the RDA, unsubstantiated risks of taking too much vitamin C have been accorded great importance, whereas the risks of not taking enough have been ignored. Real scientists understand that ‘no scientific proof' is a fancy way of saying ‘we don't like this idea.'"
Why the hate campaign?
There is a hate campaign against vitamin C promulgated by the medical community, drug industry and their paid supporters in the media. People are being told vitamin C doesn't work. The world witnessed the amazing case of New Zealand farmer Allan Smith, who was put on ECMO life-support after contracting white-out pneumonia through swine flu. Doctors were prevented from switching off Allan's machinery only after his sons threatened court action if his father was not continually administered intravenous vitamin C.
Allan's recovery was swift and damning after the appalling spectacle of officialdom scoffing at ‘useless' vitamin C as they repeatedly attempted to stop the treatment. Watch his story
to understand precisely what you are up against.
Such quoted studies which damn vitamin C as ‘useless', when conducted at all, are low-dose trials around 100-200 mg. Other stories spook the public that vitamin C is harmful. These are utterly without foundation. There is not one scientific paper which shows high intakes of vitamin C cause kidney stones or any other problem. When too much is taken, the bowels become loose - the so-called bowel tolerance threshold - which is actually the best indicator of tissues saturated with C.
If you are sick, one effective way of high-dosing C is to get a glass bottle (1 - 1.5 litres), put in 20-30 g of vitamin C powder and fill with water, then drink throughout the day. Replenish when necessary. This ensures high potency dosage is delivered on a regular basis simultaneously with water intake. Vitamin C is very safe for kids and highly effective when they get fevers or childhood ailments. For adults, mega-dose vitamin C (oral and IV) is effective for all forms of infection, flu, muscle weakness, muscle pain, chronic lower back pain, general pain management, periodontitis, etc. Andrew Saul concludes:
"Dr. Klenner recommended daily preventive doses of 10,000 to 15,000 mg/day. He advised parents to give their children their age in vitamin C grams (1 g = 1,000 mg). That would be 2,000 mg/day for a two year old, 9,000 mg/day for a nine year old, and for older children, a levelling-off at about 10,000 mg/day.
As for me, I simply say, "Take enough C to be symptom free, whatever that amount may be." It worked for my family. I raised my children all the way into college and they never had a dose of any antibiotic. Not once. It is high time for medical professionals to welcome vitamin C megadoses and their power to cure the sick. Cure is by far the best word there is in medicine. It would seem that you cannot spell "cure" without "C." I do not think Dr. Klenner would dispute that."
Because smoking lowers levels of ascorbic acid in the body, researchers theorised that Vitamin C supplementation may affect blood lead levels in smokers. A clinical study was performed on 75 adult men 20 to 30 years of age who smoked at least one pack of cigarettes per day, but had no clinical signs of ascorbic acid deficiency or lead toxicity. Subjects were randomly assigned to daily supplementation with placebo, 200 mg of ascorbic acid, or 1000 mg of ascorbic acid. After one week of supplementation, there was an 81% decrease in blood-lead levels in the group taking 1,000 mg of ascorbic acid daily. Intravenous (IV) C
Studies show that when vitamin C is given intravenously in mega-doses, it is selectively toxic to cancer cells. Dosage varies from 30,000 mg to 200,000 mg IV/24 hours, sometimes more. There are no reported side-effects aside from a dry mouth and a spacey feeling in the head. The treatment is thought to work by producing large amounts of hydrogen peroxide at the cancer site (massive oxygen).
Recent press reports of the effectiveness of this simple treatment have rekindled the public's interest. Sadly, the pharmaceutical/medical establishment remains sceptical, chiefly due to the treatment's lack of profitability and patentability. www.doctoryourself.com
"There are many good reasons to give large quantities of vitamin C to a cancer patient. Ascorbic acid strengthens the collagen ‘glue' that holds healthy cells together and retards the spread of an existing tumor. The vitamin also strengthens the immune system and provides a surprising level of pain relief.
But there is more. Vitamin C has been shown to be preferentially toxic to cancer cells. Laboratory and clinical studies indicate that, in high enough doses, one can maintain blood plasma concentrations of ascorbic acid high enough to selectively kill tumor cells. If you have not heard about this, it is probably because most of the best publicized (but worst designed) vitamin C and cancer studies simply have not utilized high enough doses.
Now, however, Hugh Riordan MD and colleagues have treatment data which ‘demonstrate the ability to sustain plasma levels of ascorbic acid in humans above levels which are toxic to tumor cells in vitro and suggests the feasibility of using AA as a cytotoxic chemotherapeutic agent.'" Vitamin P (bioflavonoids)
Another part of the Vitamin C ‘complex'. Dr Albert Szent-Gyorgi, 1937 Nobel Laureate for his isolation of vitamin C, later found other factors intrinsic to the action of C. Originally believed to be a single nutrient, Vitamin C became the subject of further testing by Szent-Gyorgi, who fought long and hard to have the co-factor (bio)flavonoids included in the C complex.
Coining the new bioflavonoids ‘Vitamin P', Szent-Gyorgi argued that they were essential for proper functioning of the human organism, derived from plant pigments known as the flavonols and flavones. Bioflavonoids are widely accepted today for their health benefits and are available in hydroxylated and methoxylated forms. They are derived from the pith of fruits (mostly citrus). The term ‘Vitamin P', on the other hand, has been less well received by the medical czars.
Further resources The Essential Guide to Vitamin C
by Phillip Day and Nicholas Cockayne Vitamin C complex plus bioflavonoids
(400 g)  Simon JA, Hudes ES
"Relationship of Ascorbic Acid to Blood Lead Levels", Journal of the American Medical Association
, 1999;281:2289-2293. 
Hickey Steven and Hilary Roberts, Ascorbate,
Lulu, 2004  Klenner FR
"The significance of high daily intake of ascorbic acid in preventive medicine", pp.51-59, in: A Physician's Handbook on Orthomolecular Medicine
, Third Edition, Roger Williams, PhD, ed. Keats, 1979  www.doctoryourself.com
and www.orthomolecular.org  www.doctoryourself.com/cathcart_thirdface.html
& www.doctoryourself.com/titration.html  www.doctoryourself.com  Dawson EB, Evans DR, Harris WA, Teter MC, McGanity WJ
"The effect of ascorbic acid supplementation on the blood lead levels of smokers", J Am Coll Nutr
. 1999 Apr;18(2):166-170  www.dailymail.co.uk/health/article-362137/Vitamin-C-jab-combat-cancer
See the documentary, Food Matters,
available from www.credence.org